Molecular Imaging of Activated Matrix Metalloproteinases in Vascular Remodeling
نویسندگان
چکیده
منابع مشابه
Molecular imaging of activated matrix metalloproteinases in vascular remodeling.
BACKGROUND Matrix metalloproteinase (MMP) activation plays a key role in vascular remodeling. RP782 is a novel indium (111)In-labeled tracer with specificity for activated MMPs. We hypothesized that RP782 can detect injury-induced vascular remodeling in vivo. METHODS AND RESULTS Left common carotid artery injury was induced with a guidewire in apolipoprotein E(-/-) mice. Sham surgery was perf...
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Atrial fibrillation (AF) is a common arrhythmia, affecting approximately 5% of the population older than 65 years; the arrhythmia is associated with significant morbidity and mortality, and it is challenging and often frustrating to treat (1,2). There is a tendency for AF to become chronic and more resistant to cardioversion with increasing duration of the arrhythmia (3). Although the details a...
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ژورنال
عنوان ژورنال: Circulation
سال: 2008
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.108.789743